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The effects of Modalert 200 typically last for 12–15 hours, depending on individual factors such as metabolism, dosage, and overall health. While the wakefulness-promoting effects begin to taper off after this period, trace amounts of the drug can remain in your system for up to 2-3 days due to its half-life of approximately 12–15 hours. This extended duration is why Modalert is generally taken early in the day to avoid interfering with nighttime sleep. If taken later in the day, its stimulating effects may persist, potentially causing insomnia or disrupted sleep.